伤寒患者血清C_3、C_4及IFN-γ的检测

Measurement of C_3、C_4 and IFN-γ levels in the serum of patiants with typhoid fever

目的 探讨血清C3、C4 及γ干扰素 (IFN γ)在伤寒发病中的变化及其意义。方法 应用免疫透射比浊法、双抗体夹心ELISA法分别检测 30例伤寒患者及 2 0例健康正常人血清中的C3、C4 和IFN γ水平。结果 伤寒患者急性期血清中的C3、C4 及IFN γ水平均明显高于正常对照 (P <0 .0 1)。结论 初步研究表明血清C3、C4 及IFN γ水平在伤寒患者急性期升高 ,是参与伤寒发生、发展的重要免疫调节分子。

Objective To explore the significances serum levels of C 3?C 4 and IFN γ in patiants with typhoid fever. Methods C 3?C 4 and IFN γ levels of the serum were measured with Immunonephelomytry ?enzyme linked immunoadsorbent assay(EILSA) in 30 patiants with typhoid fever and 20 healthy youth. Results compared with the controls, the average serum levels of C 3?C 4 and IFN γ were much higher in patiants with acute typhoid fever(P<0.01). Conclusions Pilot study indicated the average serum levels of C 3?C 4 and IFN γ increased in patiants with acute typhoid fever, the serum C 3?C 4 and IFN γ were important immune adjustable molecules in the occurrence and development in typhoid fever.