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侧脑室注射血管紧张素Ⅱ促进内源性洋地黄样因子释放 被引量：8

Intracerebroventricular administration of angiotensin Ⅱ triggers rele ase of endogenous digitalis-like factor
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摘要 目的　探讨侧脑室注射血管紧张素Ⅱ对内源性洋地黄样因子 (EDLF)释放的影响。方法　大鼠侧脑室注射血管紧张素Ⅱ及侧脑室注射Saralasin或损毁第三脑室前腹区 (AV3V)预处理 ,放射免疫方法测定血清EDLF浓度的变化。结果　侧脑室注射AngⅡ可引起血清EDLF浓度升高 ;Saralasin预处理或海人酸损毁AV3V区可阻断侧脑室注射AngⅡ引起的血清EDLF升高效应。 Experiments were performed on anesthetized SD rats. After itracereb roventricular(icv) injection of angiotensin Ⅱ(AngⅡ,100ng/rat), serum endogen ous digitalis like factor(EDLF) concentration increased obviously. These effec ts could be antagonized by icv pretreatement of saralasin, a AngⅡ receptor ant agonist(1μg/rat) or by the anteroventral third ventricle(AV3V) lesions. These results suggest icv injection of Ang Ⅱ induces EDLF release.
作者 张成标 王勇 陈远寿 魏振宇 王箐 任伟
机构地区 遵义医学院生理学教研室
出处 《遵义医学院学报》 2001年第3期213-216,共4页 Journal of Zunyi Medical University
基金 贵州省教育厅科研基金项目 ( 90 3 3 )
关键词 血管紧素Ⅱ 侧脑室 第三脑室前腹区 内源性洋地黄样因子 angiotensin Ⅱ cerebroventricle anteroventra l third ventricle endogenous digitalis like factor
分类号 R335 [医药卫生—人体生理学]
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参考文献6

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同被引文献31

  • 1刘红,罗蕾,高原.鼠肾近曲小管微分离技术[J].川北医学院学报,2004,19(2):10-12. 被引量：13
  • 2罗蕾,刘红,高原.大鼠侧脑室注射血管紧张素Ⅱ抑制近曲小管Na^+,K^+-ATPase活性[J].遵义医学院学报,2005,28(3):231-234. 被引量：3
  • 3刘爱东,罗蕾,高原.大鼠AV3V注射血管紧张素Ⅱ对内源性洋地黄样因子释放和肾皮质Na^+,K^+-ATP酶活性的影响[J].遵义医学院学报,2005,28(6):517-520. 被引量：2
  • 4高原,罗蕾,刘红.大鼠单根近端肾小管Na^+-K^+-ATPase活性测定方法的改进(英文)[J].生理学报,2007,59(3):382-386. 被引量：11
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  • 10da Silva RK, Saad WA, Renzi A et al. Effect of lateral hypothalamus lesions on the water and salt intake, and sodium and urine excretion induced by activation of the median preoptic nucleus in conscious r:.ts[J]. J Auton Nerv Syst, 1995,53 (2-3): 195 -204.

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遵义医学院学报
2001年 第3期

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