慢性乙型肝炎患者血清HA、Ⅳ-C的变化及影响因素的研究

Changes of serum levels of hyaluronic acid and type Ⅳ collagen and their influence factors in patients with chronic hepatitis B

目的 了解慢性乙型肝炎病程中对纤维化指标的影响因素。方法 对 10 0例慢性乙型肝炎患者及 15例正常人群采用RIA法 ,检测了血清透明质酸 (HA)、Ⅳ型胶原 (Ⅳ -C)含量 ;应用定量PCR法检测血清HBVDNA。结果 各组慢乙肝患者血清HA、Ⅳ -C含量随着病程的进展依次增高 ,慢乙肝轻度 <中度 <重度。血清HA、Ⅳ -C随HBVDNA复制水平的增高呈下降趋势 ;随病程的延长呈上升趋势。结论 血清HA、Ⅳ -C为反映肝脏纤维化程度的指标 ,也可作为判断慢乙肝病情严重程度的指标。慢乙肝患者HBVDNA复制水平降低 ,肝脏的炎症病变及纤维化增生仍可继续发展。随着肝脏病变时间延长 ,肝脏纤维化程度不断加重。

WT5”BZ] Objective To investigate the factors influencing fibrosis indicators during the course of chronic hepatitis B(CHB). Methods One hundred patients with CHB and 15 normal subjects were studied. Their serum hyaluronic acid(HA)and type Ⅳ collagen (Ⅳ C)were measured by radioimmunoassay (RIA),and HBV DNA was detected quantitatively by polymerase chain reaction(PCR). Results Serum levels of HA and Ⅳ C in CHB patients increased with disease development.The two serum components had a decreasing trend with the HBV DNA duplicate level increase and an increasing trend with the disease course prolonging. Conclusion Determination of serum HA and Ⅳ C may be of value in diagnosing hepatic fibrosis and hepatitis B.The duplicate level of HBV-DNA decreases in CHB,while the liver inflammation and proliferation of hepatic fibrotic tissue still develop.With the development of the liver disease,liver fibrosis becomes more serious. [WT5”HZ]