参麦注射液治疗左心功能不全31例

Effcet of Shenmai Injection in Treatment with 31 Cases of Left Ventricular Dysfunction

目的 :观察参麦注射液治疗左心功能不全的疗效。方法 :采用随机单盲法将 61例患者分为两组。治疗组 3 1例 ,给予参麦注射液每次 60mL ,加入 5 %葡萄糖注射液 5 0mL中 ,静脉滴注 ,qd ,连续 2周 ;对照组 3 0例 ,给予黄芪注射液 60mL ,用法疗程同治疗组。用多普勒超声心动图评定心功能变化。结果 :治疗组用药后左心收缩功能指标心排血量 (CO)、射血分数 (EF)值显著增大 (P <0 .0 1) ,舒张功能指标 (E、A、E A、DC)明显改善 (P <0 .0 1)。对照组仅收缩功能指标改善 (P <0 .0 5 ) ,舒张功能指标无变化 (P >0 .0 5 )。结论 :参麦注射液是治疗左心功能不全的一种有效而安全的药物 ,疗效优于黄芪注射液。

Objective:To observe the effects of Shen-mai injection(SMI) in treating left ventricaular dysfunction. Methods:61 LVD patients were randomly divided into an observation group(31 cases) and a control group(30 cases). The observation group was treated with SMI and the control groups with Astragalus membranaceue injection(AMI). Both groups of patients were treated for 2 consecutive weeks. The cardiac function was assessed by Doppller echocardiograpy before and after treatment. Results:It was showed that the left ventricular systilic function(CO and EF) and left ventricular diastolic function parameters (E, A, E/A, DC) were improved (all P<0.01) in SMI group. In the AMI group, only the left ventricular systolic function rather than the left ventuicular diastolic function parameters (CO, EF) were improved (P<0.05). NO side effect was found in the patients treated with SMI. Conclusion:SMI is more effective than AMI in treating LVD.