c－myc基因表达水平是评价大肠腺瘤恶变倾向的一个临床实用的指标

The c-myc Expression May Prove to be a Useful Marker to Evaluate the Malignant Potential of Colorectal Polyps

本文作者利用Ｎｏｒｔｈｅｒｎ印迹杂交、斑点杂交技术，比较了大肠癌、腺瘤（癌前期病变）与正常粘膜组织中ｃ－ｍｙｃ基因的表达水平。实验结果表明：在大多数结肠癌（１４／１７）和一部分腺瘤（直径＞１ｃｍ）中ｃ－ｍｙｃ基因的表达水平显著增高，而另一部分小腺瘤（直径（１ｃｍ）中仅有轻度增高。我们认为：ｃ－ｍｙｃ基因的表达水平对于判断大肠腺瘤是否恶变是一个具有潜在临床应用价值的指标。

We have compared the expression of c-myc in colorectal carcinomas and adenomas (pre-malignant stages)tissues with that in adjacent normal mucosas as the controls,by employing Northern blot and Dot bolt analysis. The results showed that in most colorectal carcinomas and some adenomas(>1cm in diameter) c-myc gene is expressed at remarkably high levels,but not very high in some other adenomas(<1cm in diameter).The levels of cmyc expression are related to the size of adenomas,hence may prove to be a useful marker for early diagnosis and prognosis of colorectal adenoma patients. We also searched for some simple,methods for this purpose.