汕头市畸形儿巨细胞病毒感染的检测

Cytomegalovirus Detection in Congenital Malformation in Shantou

宫内病毒感染尤其是巨细胞病毒（ＣＭＶ）感染是致畸的重要原因之一，为了解我市畸形儿病毒感染的状况，探讨ＣＭＶ在致畸上的作用及相关性，本室从汕头市各医院收集了２４例畸形儿（无脑儿、脊柱裂、异位心、多发性畸形、巨大肝等），取母、婴配对标本（包括羊水、母血、宫颈分泌物、乳汁及畸形儿心血、咽拭子）共１２８份进行常规病毒分离、鉴定，并用ＥＬＩＳＡ法测定母、婴血清中抗ＣＭＶ、ＩｇＧ、ＩｇＭ抗体。结果从２４例畸形儿中分离到ＣＭＶ１例，ＨＳＶ－２型１例，检出ＣＭＶ－ＩｇＭ３例（其中１例为ＣＭＶ分离阳性），病毒检测阳性率为１６．６７％（４／２４），而ＣＭＶ占病毒感染的３／４，初步结果提示本市畸形儿病毒感染因素不容忽视，而在病毒感染中以ＣＭＶ为主要病原。

Vrius infection in Uterus is one of the most important factors that lead to deformation of infants. In order to know the state of virus infection in congenital malformation in Shantou City, 128 samples from 24 cases of various abnormal infants were collected for virus isolation and anti-CMV IgG and IgM detection. The results showed that out of 24 cases there were 1 case positive for CMV, 1 case positive for HSV-2 isolation, and 3 cases positive for anti-CMV-IgM(1 case was also positive for CMV isolation). The infection rate of virus is 16. 67%(4/24) and 3 out of 4 cases(3/4)were CMV infection. The results indicated that virus infection may be one of the important factors for deformation of infants and CMV is a major pathogen.