肝病患者血浆心钠素的变化

Plasma Concentration of Atrial Natriuretic Factor in Patients with virus Liver Disease

本研究用放射免疫法对各类病毒性肝病的血浆心钠素（ＡＮＦ）浓度进行了分析。结果发现：急性肝炎、慢性肝炎、肝硬化并腹水各组的血浆ＡＮＦ浓度均比对照组显著升高（Ｐ＜０．００１），特别是肝硬化并腹水组较其他各组血浆ＡＮＦ升高更为明显（Ｐ＜０．００１）。在慢性肝炎组，血浆ＡＮＦ浓度与ＩｇＧ、ＩｇＡ、ＣＩＣ之间呈显著的正相关（ｒ分别为０．４３７，０．５０７，０．６６４，Ｐ＜０．０５）。但在治疗１月前后对照的急性肝炎组、慢性肝炎组血浆ＡＮＦ浓度无显著性差别。提示各型肝病血浆ＡＮＦ浓度升高与肝实质性损害有关，在肝硬化并腹水者，则可能与心钠素的合成、贮存、释放增加，降解减少有关，但确切机理有待进一步研究。

This study was undertaken to access relationship between virus liver diseases and plasma concentration of atrial natriuretic factor(ANF). Plasma ANF was measured by radioimmumoassay. Plasma ANF was signifi-cantly higher in patients with acute hepatitis and in patients with chronic hepatitis and in patients with cirrhosis and ascites than in healthy volunteers(P<0.001). There were significant relation-ship between plasma ANF and IgG(r=0. 437,P<0.05), and IgA(r=0. 507,P<0.05), and CIC(r=0.664,P<0.01). We hadn't found plasma ANF having markedly difference before and after one month treatment in patients with acute hepatitis and in patients with chronic hepatitis.These results would suggest that the elevated plasma levels of ANF in patients with virus liver diseases appear to be clearly related to an impaired hepatic extraction of ANF. The rise in plasma ANF in patients with cirrhosis and ascites might due to increased synthesis, storage, release and decreased degradation of ANF.