头孢呋辛和罗红霉素联合治疗老年肺炎比较研究

Comparative Study on Theraputic Effect of Ally Cefuroxime and Roxithromycin on Treatment of the Aged with Pneumonia

目的比较头孢呋辛单用和联合罗红霉素治疗老年人获得性肺炎的疗效和安全性.方法 192例患者随机分成2组,单用头孢呋辛组(Ⅰ组)95例,用3 g/d静脉滴注;联合罗红霉素组(Ⅱ组)97例,加用罗红霉素300mg/d.结果 2组临床总有效率分别为78.9%和80.4%,差异无显著意义(P＞0.05),细菌阳性率34.9%(67/192),细菌清除率分别为77.1%和79.5%,在统计学上差异无显著意义(P＞0.05).患者用药过程中无不可耐受的副作用.结论在治疗老年人获得性肺炎中,头孢呋辛单用和联合罗红霉素都是安全有效的,未见联合用药组的疗效提高或降低.

Objective To evaluate and compare the efficacy and safety of cefuroxine or Cefuroxine and Roxithromycin in the treatment of the aged with acquired character pneumonia.Methods 192 patients were devided into two groups.95 patients received 3.0g Cefuroxime introvenously dropping a day (group Ⅰ);97 patients used Cefuroxime and Roxithromycin together (groupⅡ)and took orally 300mg Roxithromycin a day.Results The overall efficacy rate of group Ⅰand group Ⅱ were 78.9% and 80.4%.It was not respective difference ( P >0.05).The positive rate of bacteriology was 34.9% (67/192).The eradication rate of two groups were 77.1% and 79.5%( P >0.05).No adverse events occured.Conclusion It is efficacy and safety that cefuroxine is used only or Cefuroxine and Roxithromycin were used together in the treatment of the aged with acqaired character pneumonia.The efficacy of group Ⅱ did not improve or reduce.