脑功能光学成像研究进展

Optical Imaging of Functional Brain:An Introductory Review

首先对脑功能成像技术的研究背景和发展历程进行了简单的回顾 ,然后对脑功能光学成像方法进行了分类综述 ,主要介绍了电压敏感性染色成像、内源光学成像、光学相干层析成像、神经元活动相关光信号成像等成像方法的原理和最新进展 ,并总结了选择光学成像系统所应考虑的因素 ,最后 ,通过对各种成像方法的分析和比较 ,提出了改进和完善脑功能光学成像技术的建议 。

The background and development of functional brain imaging are briefly reviewed. The optical imaging technologies of brain function are then introduced and classified. Several methods including voltage sensitive dyes imaging, optical imaging based on intrinsic signals, optical coherence tomography imaging, event related optical signals imaging are summerized and compared, and the key factors of how to choose an optical imaging system recording fast brain activity are summed up. Based on the analysis and comparison, we suggest how to improve functional brain imaging technologies and point out possible directions for further research .