热性惊厥导致T细胞功能改变的观察

Immune-Functional Changes of T-lymphocytes in Children with Febrile Convulsions

目的 :探讨热性惊厥患儿外周血T淋巴细胞免疫功能的变化。方法 :应用APAAP法检测 82例热性惊厥患儿、40例上呼吸道感染患儿及 40例正常小儿T淋巴细胞亚群、CD2 5抗原在自然状态和PHA激活后的活化状态的百分率。结果 :热性惊厥患儿外周血中 ,CD3、CD4 、CD4 /CD8比值 ,均显著低于两对照组 ;热性惊厥患儿在自然状态下的CD2 5抗原表达率明显低于两对照组 ,经PHA刺激后 ,CD2 5抗原表达在各组均显著增多 ,但热性惊厥组仍低于两对照组。结论 :热性惊厥患儿存在着细胞免疫损害 ,这可能是热性惊厥发生和复发的一个重要因素。预防热性惊厥复发 ,必须从提高细胞免疫功能着手。

Objective: To investigate the immune-functional changes of T-lymphocytes of peripheral blood in children with febrile convulsions. Methods: Eighty-two children with febrile convulsions, forty with acute upper respiratory tract infection and forty normals were studied. The distribution of T-lymphocytes subsets, the expression of active marker CD 25 + before and after PHA stimulation were investigated by APAAP assay. Results: Compared with the other control groups, the percentages of CD 3, CD 4 and CD 4/ CD 8 ratio of T-lymphocytes were all significantly depressed in the peripheral blood in children with febrile convulsions.The expression rate of CD 25 antigen before PHA stimulation was significantly lower than those in two control groups. After PHA stimulation, the expression rates of CD 25 antigen were all higher than before, but the rate of the febrile convulsion group was still lower than those of the control groups. Conclusion: Impairment of T-lymphocytes-mediated immune function was associated with febrile convulsion and it might be a important cause of occurrence of febrile convulsion in children.For prevention and reduction of recurrence and subsequent brain damage, it is important to improve the T-lymphocytes_mediated immune function of the children with febrile convulsions to normal level.