摘要
目的:研究脑梗死急性期患者脑脊液(CSF)和血浆中血小板颗粒膜蛋白-140(GMP-140)和血管性假血友病因子(vWF)含量的变化及临床意义。方法:应用双抗夹心酶联免疫吸附试验(ELISA)法测定了34例脑梗死急性期病人CSF和血浆中GMP-140、vWF的含量。结果:病人组CSF和血浆中GMP-140、vWF含量较正常对照组显著升高(P<001)。结论:脑梗死患者急性期存在高凝状态和血小板活化功能亢进以及脑血管内皮的损伤;检测CSF中GMP-140和vWF含量的变化对进一步了解急性脑梗死的发病机理和治疗提供了理论依据,对于观察病情演变、判断预后均有重要的临床意义。
Objective:To study the contents and clinical
significance of Alphagranule membrane protein-140(GMP-140),von Willebrand factor(vWF)in
cerebrospinal fluid(CSF) and plasma of patients with cerebral infarction.Methods:With ELISA
method, GMP-140,vWF in CSF and plasma of 34 cases suffering from cerebral infarction were
measured and compared Results:During the acute period of cerebral infarction,the contents of
GMP-140,vWF in CSF and plasma were higher significantly than that of the control group( P <0
01).Conclusions:The GMP-140 and vWF in CSF are the specific parameters of the
hypercoagulable state and of the damage at endotheliocyte of cerebral vessels in the patients
with cerebral infarction.The measurement may be useful for study of pathological
mechanism,differential diagnosis,therapy and prognosis of patients with ischemic
cerebrovascular diseases.
出处
《宁夏医学院学报》
1999年第4期237-239,共3页
Journal of Ningxia Medical College