失代偿期肝硬化患者低钠血症与低蛋白血症关系的探讨

The Study of Relationship Between Hyponatremia and Hypoproteinemia in Decompensated Cirrhosis Patients

目的：探讨失代偿期肝硬化患者低钠血症与低蛋白血症的关系。方法：对５４例失代偿期肝硬化患者的８２份血标本进行的血电解质及血浆白蛋白测定结果进行分析。结果：失代偿期肝硬化患者低钠血症的发生率为４６％。血浆白蛋白的平均值在血钠正常组（Ｎａ＋＞１３５ｍｍｏｌ／Ｌ）为２６３ｇ／Ｌ；在轻度低钠组（Ｎａ＋１３１～１３５ｍｍｏｌ／Ｌ）为２４１ｇ／Ｌ；在中度低钠组（１２６～１３０ｍｍｏｌ／Ｌ）为２２１８ｇ／Ｌ；在重度低钠组（Ｎａ＋＜１２５ｍｍｏｌ／Ｌ）为１８６８ｇ／Ｌ。血浆钠降低程度与低蛋白血症程度呈正相关ｒ＝０６９（Ｐ＜０００１）。结论：低蛋白血症是导致失代偿期肝硬化患者低钠血症的一个重要原因。

Objective: To study the relationship between hyponatremia and hypoproteinemia in decompensated cirrhosis.Methods:82 test results of blood electrolyte and plasma protein from 52 cases with decompensated cirrhosis were analysed.Results:46% hyponatremia was occurred in patients with decompensated cirrhosis.The mean values of plasmaalbumin were 26. 3g/L,24.lg/L,22.18g/L,18.68g/L in the groups of normal serum-sodium level,(Na +131～ 135mmol/L)mild hyponatremia(Na +131～135mmol/L),moderate hyponatremia(Na +126～ 130mmol/L),and severe hyponatremia(Na +<125mmol/L)respectively.Serum-sodium levels were excellently correlated with the degrees of hypoproteinemia.Conclusion:Hypoproteinemia my be a cause of hyponatremia in patients with decompensated cirrhosis.