病毒性肝炎临床分型与肝脏纤维化血清学检测的关系研究

Study on the Relationship between Clinical Types of Viral Hepatitis and Liver Fibrosis

目的 :探索能提高检测肝脏早期纤维化的敏感血清学指标。方法 :对 10 0例各种类型肝炎联合检查血清透明质酸 (HA)、层粘连蛋白 (LN)、Ⅳ型胶原 (Ⅳ C)、Ⅲ型前胶原肽 (PⅢP)及甲胎蛋白 (AFP)的检测 ,并对其结果进行对比分析。结果 :前四项指标分别在急性肝炎、慢性肝炎的中度、重度和肝硬化中依次升高 ,差异有显著性 (P <0 .0 5 )。其升高的程度与肝组织受损程度显示出良好的正相关性。AFP的检测结果较正常值有轻度的升高 ,差异有显著性 (P <0 .0 5 ) 。

Objective: To investigate the relationship between clinical types of viral hepatitis (VH) and liver fibrosis (LF). Methods: We took the levels of hyaluronate acid (HA), laminin (LN), collagen type Ⅳ (Ⅳ_C), type Ⅲ procollagen (PC Ⅲ) and α_fetoprotein (AFP) in serum to be the indication of the degree of LF. The aforementioned examinations were carried out in 100 cases with different clinical types of VH. Results: The first four levels were increased progressively in acute VH, chronic VH (moderate type, severe type) and cirrhosis ( P <0.05). The levels of AFP in all of the different clinical types of VH was higher than that in the normal ( P <0.05). There was no difference on the levels of AFP between every two types of VH. Conclusions: The more severe and longer of liver damage in VH, the higher of the degree of LF.