摘要
目的 :观察吸入性损伤及部分液体通气后血清一氧化氮 (NO)、超氧化物歧化酶 (SOD)及丙二醛 (MDA)的变化情况 ,探讨部分液体通气对吸入性损伤的治疗作用。方法 :制作 8条犬吸入性损伤模型 ,将氟碳 (FC 77)缓慢注入肺内 ,实施部分液体通气 ,然后分别于致伤前、致伤后 2h及部分液体通气治疗 90min后抽血测NO、SOD及MDA。结果 :致伤后NO、MDA值明显升高而SOD值却明显下降 ,与致伤前相比 ,有显著性差异 (P <0 .0 5 ) ;随着部分液体通气的进行 ,NO、SOD基本回复到致伤前的水平 ,与致伤前相比 ,差异不大 (P >0 .0 5 ) ;而MDA回复则较慢 ,虽比致伤后显著下降 (P <0 .0 5 ) ,但仍高于致伤前水平 (P <0 .0 5 )。结论 :部分液体通气可以通过抗脂质过氧化作用和减少体内一氧化氮来改善肺组织损伤 。
Objective: To observe the effects of partial liquid ventilation (PLV) on the concentrations of NO, SOD and MDA in serum in inhalation_injured dogs. Methods: The inhalation_injured dogs ( n =8) were treated with PLV (instillation of perfluorocarbon slowly into the lungs). The concentrations of NO, SOD and MDA in serum were detected before and 120 min after injury, and 90 min after PLV. Results: The concentrations of NO and MDA at 120 min after injury were higher than before injury ( P <0.05), meanwhile the concentration of SOD became lower ( P <0.05). All of the concentrations of NO, SOD and MDA recruited at 90 min after PLV. Conclusion: The treatment with PLV may be effective to inhalation_injured dogs by reducing the levels of NO and MDA, and enhancing the level of SOD.
出处
《江西医学院学报》
2000年第4期121-123,共3页
Acta Academiae Medicinae Jiangxi
基金
国家自然科学基金资助项目
江西省主要学科跨世纪学术和技术带头人培养计划
