非甾体抗炎药致上消化道出血的临床特征

Clinical characteristics of NSAIDs induced upper gastrointestinal bleeding

目的 研究非甾体抗炎药（ NSAIDs）致上消化道出血的临床特征。方法 调 查上海 4家医院的上消化道出血住院患者的临床资料，根据出血前 10d内是否服用过 NSAID s,将其分为两组进行比较。结果 424例上消化道出血患者中有 70例 (16.51％ )服用过 NS AIDs。两组比较，患者的性别、消化道溃疡史、出血程度、病变大小及部位比较差异无显著 性（ P >0.05）；但 NSAIDs组患者的年龄偏大，较多患者有消化道出血史、心血管病史， 出血前消化道症状不明显，溃疡或糜烂更易多发，平均住院天数明显减少（ P<0.05)。结论 应采取适宜策略降低NSAIDs的不良反应。

Objective To study the clinical characteristics of NSAIDs i nduced upper gastrointestinal bleeding(UGIB). Methods 424 patients with UGIB in 4 hospitals were recorded and investigated.This cohort was divided into 2 group s based on whether consumed NSAIDs within 10 days previous to the onset of bleed ing. Results 70(16.15％ ) of 424 patients consumed NSAIDs.There was no signifi cant difference in the multivariate analysis between the 2 groups regarding sex of patient,previous history of peptic ulcer,ulcer size and location and degree o f bleeding(P >0.05).NSAIDs users were older than nonusers by a mean of 11 years, more likely to have a history of UGIG (P=0.002)and cardiac vessel disease(P=0.00 0).NSAIDs users have more number of ulcer or erosion(P=0.001)and fewer hospital stay(P=0.011). Conclusion Proper measures should be employed to decrease NSAIDs induced GI complications.