摘要
The effects of zinc deficiency on the serum cortisol and adrenocorticotrophic hormone (ACTH) concentration,and the cerebrum nitric oxide synthase (NOS) activity in rats were studied.Growing rats were allotted to three groups,which were zinc deficiency (ZD),paired fed (PF) and zinc supplementation after feeding zinc deficient food for 21 days (ZS).The duration of feed test was 35 days.Compared with PF rats,serum cortisol concentration in ZD ones was significantly increased,whereas serum ACTH concentration and cerebrum NOS activity were significantly decreased.The results suggested that zinc might influence the metabolism of hypothalamic hypophysial adrenocortical axis and NOS.
就缺锌对大鼠血液皮质醇和促肾上腺皮质激素 (ACTH)含量以及大脑皮质NO合酶活性的影响进行了研究。生长大鼠随机分为 3组 ,即缺锌组、对喂组和缺锌补锌组 (先饲喂缺锌饲料 2 1天后再补锌 )。饲养实验的持续时间为 35d。与对喂组比较 ,缺锌组大鼠血液中皮质醇含量显著升高 ,而血液ACTH浓度以及大脑皮质NO合酶活性明显降低。此结果提示锌可影响下丘脑—垂体—肾上腺皮质轴和NO合酶的代谢。
基金
SupportedbyNationalNaturalScienceFoundationofChina (No 3970 0 12 0 )andbyNationalEducationMinistrygrants (No A9410 7)
