慢性肝病患者血清中4种自身抗体测定及临床意义

Analysis of four kinds of autoimmune antibodies in sera of patients with viral hepatitic disease

目的 :探讨慢性肝病患者自身免疫状况及其临床意义。方法 :应用ELISA法与间接免疫荧光法检测不同类型肝病患者血清中类风湿因子 (RF) ,抗核抗体 (ANA)、抗甲状腺微粒体抗体 (Anti TM)、抗双链DNA抗体 (dsDNA Ab) 4种自身抗体。结果 :6 3例慢性乙肝病毒性肝病组检出一种以上自身抗体者 1 2例 ( 1 9 1 % ) ;40例丙肝病毒性肝病组检出一种以上自身抗体者 1 2例 ( 30 % ) ,明显高于对照组酒精、药物性肝炎组 5 7% ,3 3% (P <0 0 1 )。结论 :自身免疫反应参与慢性肝病的发生发展过程 ,慢性肝病患者自身抗体测定 ,对于指导临床治疗具有一定意义。

Objective:To analyse clinical signification of four kinds of autoimmune antibodies in the patients with viral hepatitis.Methods:ANA RF,anti TM and dsDNA Ab in sera of patients with viral hepatitic disease were detected by means of indirect immune fluerscence(IIF) and ELISA.Results:12 of 63 (19.1%) were only one kind of autoimmune antibody in sera of patients with hepatitis B and 12 of 40(30%) of patients with hepatitis C.There were significantly higher than those of alcoholic and drug hepatitis group(P<0 01).Conclusion:autoimmune reaction was participated in the couse of viral hepatic disease development and there was some clinical significant in detecting autoimmune antibodies in sera of patients with viral hepatitic.