用螯形主体分子的识别功能选择分离小茴香挥发油中的茴香醚

SELECTIVE ISOLATION OF ANETHOLE FROM VOLATILE OIL OF FOEMICULUM VULGARE MILL BY INCLUSION CRYSTALLINE WITH CHELA-SHAPE HOST

目的 用主客体分子包结法选择分离小茴香挥发油中的化学成分。方法 利用超分子化学的分子识别功能 ,采用螯形主体分子trans 1,2 二苯基 1,2 苊二醇作为主体分子 ,小茴香挥发油的化学成分作为客体分子 ,螯形主体分子可与其中有互补性的化学成分形成包结化合物 ,以晶体形式析出。结果 选择性地识别小茴香挥发油中的茴香醚并形成包结物晶体 ,用Kugelrohr真空蒸馏技术将茴香醚从包结物晶体中分离出 ,产率 11 2 %。采用IR、粉末XRD分析方法确定了包结物的形成。采用IR ,1 HNMR和MS等分析方法 ,确定了被分离的化学组分的结构为反式茴香醚。结论 此法分离挥发油化学组分有选择性高、速度快、方法简单等优点。

AIM To isolate the components from the volatile oil of Foemiculum vulgare Mill. METHODS According to the function of molecular recognition of supramolecular chemistry, chela shape molecule, trans -1,2-biphenyl-1,2-acenaphthendiol was used as host molecule and the volatile oil of Foemiculum vulgare Mill as guest molecule. Trans -1,2-biphenyl-1,2-acenaphthendiol can recognize the components that endowed with interactional complementarity and form inclusion compound as crystals. RESULTS The anethole in the volatile oil was selectively included as trans -1,2-biphenyl-1,2-acenaphthendiol which was obtained in pure state from the inclusion compound by Kugelrohr vacuum technology. The formation of inclusion compound was confirmed by means of IR and powder XRD. The structure of the selectively isolated component was elucidated as trans -anethole by means of IR, 1HNMR and MS. CONCLUSION The experimental results showed that the method is simple, rapid and selective for isolation anethole from volatile oil of Foemiculum vulgare Mill.