GLP-1-IR细胞在人类胎儿和成人胃肠道的分布

Distribution of GLP-1-IR Cells in the Gut of Foetus and Man

目的 :对国人胎儿和成人类胰升血糖素 - 1免疫反应细胞 ( GL P- 1- IR细胞 )在胃肠道中的分布作详细的研究。方法 :应用高特异性单克隆抗 GL P- 1- IR( 7- 3 6)酰胺抗体 ,采用免疫组化技术。结果 :发现在胎儿和成人的肠管中均可见到 GL P- 1- IR细胞 ( L细胞 )的存在 ,但在生长发育的不同时期肠道 L细胞的密度不同 ,各段肠管的密度也不同 ,但不同时期的 L 细胞的分布规律相同 ,均自小肠和大肠的近段向远端逐渐增大 ,密度最大为直肠。结论 :人类肠道中的 GL P- 1- IR细胞分布规律不变 。

Objective To study the localization of GLP-1-IR cells in the gut of foetus and man. Methods Immunohisochemical Sp method Was used.Results We found that the hightest GLP-1-IR cells density in both foetus and man occurred in the rectum. The density of GLP-1-IR cells was different in foetus and adult , but the distributive regulation of GLP-1-IR was the same. It showed that a continuous increase from the proximal to the distal portion on small and bowel. Conclusion The distributive regulation of GLP-1-IR in the human gut is not changed, but the density is increased.