国产西地那非对整体和离体兔海绵体的作用(英文)

Effects of domestic sildenafil on corpora cavernosum of rabbit in vivo and in vitro

目的 :观察国产西地那非对整体和离体海绵体的作用。方法 :使用兔电刺激勃起模型 ,分别比较国产或进口西地那非对整体兔海绵体腔内压和离体海绵体平滑肌张力的影响。结果 :与用药前比较 ,国产西地那非可显著增高兔海绵体腔内压的基础水平和幅度 (P <0 .0 1) ,也均能显著降低离体海绵体平滑肌的基础张力和收缩幅度 (P <0 .0 1)。同样 ,等剂量进口西地那非也有相似作用。结论 :国产或进口西地那非均可显著增强电刺激引起的兔海绵体腔内压升高效应 。

AIM: To investigate the effects of domestic sildenafil on corpora cavernosum of rabbit in vivo and in vitro. METHODS: Penile erection was induced by electrical stimulation to corpora cavernosum in rabbit model. The effects of domestic and imported sildenafil on the intracavernous pressure in vivo , and their effects on the smooth muscle tension of corpora cavernosum evoked by electrical stimulation were compared in vitro. RESULTS: Rhythmic electrical stimulation induced an increasing of intracavernous pressure, which consisted of two components, namely the tonic response and a superimposed, burst like response. Both components were significantly elevated after the administration of domestic sildenafil ( P <0.01). Domestic sildenafil also reduced the tension of the corpora cavernosum in a dose dependent manner. The same effects were observed in imported sildenafil group. CONCLUSION: Domestic or imported sildenafil can enhance the intracavernous pressure, the erection of penis and the relaxation of the corpora cavernosum elicited by electrical stimulation.