葡胺糖丙酰二茂铁的合成

Systhesis of 1,1-Di(N,N-Glucosanine Propanoyl) Ferrocene

以三氯甲烷为溶剂 ,无水三氯化铝作催化剂 ,得到 1 ,1 -二乙酰基二茂铁纯品。然后以 1 ,1 -二乙酰基二茂铁、氨基葡萄糖和甲醛为原料 ,水作溶剂 ,少量盐酸作催化剂 ,控制水浴温度在 40～ 5 0℃条件下搅拌反应 5 h,利用曼尼希反应制得医药中间体葡胺糖丙酰二茂铁。测定了 1 ,1 -二乙酰基二茂铁、葡胺糖丙酰二茂铁的最大吸收波长 ,分别是 45 6nm和 346nm。

Pure 1,1 diactyl ferrocene is successfully synthesized by the reaction of ferrocene with acetic anhydride as the solvent and aluminum chloride anhydrous as the catalyst. Then 1,1 Di(N, N glucosanine propanoyl) ferrocene is synthesized by Mannich reaction of 1,1 diactyl ferrocene with D glucosanine HCl and methanol in water, with a little HCl as the catalyst under the temperature of 40~50 ℃ for 5 h. Experiments show the maximum absorption wavelength of 1,1 diactyl ferrocene and 1,1 Di(N, N glucosanine propanoyl) ferrocene are respectively 456 nm and 346 nm. The derivatives are characterized on the basis of IR spectrum