HPP对Cl_4致大鼠肝脏灌流损伤的影响

Effect of 2-Ethyl-3-Hydroxy-6-Phenylthio-4- (1H) -Pyridinone on Perfused Rat Liver Injury Induced by Carbon Tetrachloride

对离体大鼠肝脏进行灌流，用ＣＣｌ４造成肝细胞损伤，观察了２－乙基－３－羟基－６－苯硫基－４（１Ｈ）－吡啶酮（ＨＰＰ）对 ＣＣｌ４诱发的大鼠肝脏灌流损伤的影响，结果表明 ＨＰＰ对 ＣＣｌ４引发的肝细胞损伤导致丙氨酸转氨酶（ＡＬＴ）、天门冬氨酸转氨酶（ＡＳＴ）、乳酸脱氢酶（ＬＤＨ）的升高有明显的抑制作用．提示 ＨＰＰ对离体大鼠肝脏的损伤有抑制作用．

This paper reported the effects of 2-ethyl-3-hydroxy-6.-phenylthio-4- (1H) -pyridinone (HPP) on per- fused rat liver injury induced by carbon tetrachloride. The results showed that HPP obviously reduced the release of alanine aminotransferase, aspartic aminotransferase and lactic dehydrogenase from carbon tetrachloride induced hep- atocytes. It indicated that HPP has a hepatoprotective action on isolated liver injury.