肺癌癌胚抗原的免疫组化研究

Immunohistochemical Study of Cacinoembryonic Antigen (CEA) in Lung Cancer

应用免疫组化方法(PAP),对202例肺癌切除标本,进行癌胚抗原(CEA)标记研究,鳞癌91例,CEA阳性率为78.0%,角化癌细胞内表达明显(70.4%)。腺癌95例,CEA阳性率为87.4%,以中等分化组(92.6%)多见,且与癌组织内淋巴细胞浸润程度呈正相关(P<0.05)。鳞癌CEA表达阳性者,半年病死率(4/35)明显低于阴性者(7/12)(P<0.01),可做为对患者短期(半年)预后的预测指标,而与5年生存率关系不明显。未分化癌16例,CEA阳性率为50%。

The immunohistochemical change of CEA in 202 cases of humanlung cancer were studied by PAP method. In 91 cases of squamouscell carcinoma, the positive rate of CEA was 78% and 70.4% werein keratinous squamous cancer cells. In 95 cases of adenocarcinoma,the positive rate of CEA was 87.4%, and 93.0% were in mediandifferentiational group, and directly proportional to the infilltrativedegrees of lymphocytes in cancers (P<0.05). In the CEA positivegroup of squamous cell carcinoma, the 1/2-year mortallity (4/35)was obviously less than negative (7/12) (P<0.01), and it maysuggest as a short time (1/2 year) prognostic factors of suqamouscell carcinoma. But the 5 years survival rate of the CEA positiveand negative group was not significant (P>0.05). In 16 cases ofundifferentiate carcinoma, the positive rate was 50%.