实验性家兔动脉粥样硬化血管外器官的病理学变化

Pathologic Changes of Extravascular Organs in the Process of Exprimental Atherosclerosis in Rabbits

对50办家兔实验性动脉粥样硬化的血管及血管以外心、肝、脾、肺、肾等脏器,进行了系统的病理形态学观察,试图探讨动脉粥样硬化形成过程中高脂血症对内脏器官的影响。结果表明,高脂血症不仅可以诱发家兔动脉粥样硬化,也可使受试动物产生肺炎,肝细胞广泛脂变和水变,以及全身单核巨噬细胞系统反应。并着重讨论了内脏器官病变的发病机理。

Systemic pathologic investigations were made on 50 rabbits in orderto elucidate the effect of hyperlipoidemia on internal organs (heart,liver, spleen, lungs and kidney) and out of blood vessels in theprocess of experimental atherosclerosis. The results showed thathyperlipoidemia induced not only atherosclerosis but also pneumonia,fatty and hydropic degenerations of liver cells, and response ofmonounclear macrophage system. The pathogenesis of internal organslesions were particularly discussed.