肝脏局灶性结节性增生的临床病理学观察

FOCAL NODULAR HYPERPLASIA OF THE LIVER: A CLINICOPATHOLOGICAL ANALYSIS

采用HE染色和免疫组化技术对 17例肝脏局灶性结节性增生 (FNH)进行临床病理观察。男性 12例 ,女性 5例 ,年龄 13～ 71岁 ,平均年龄 36 8岁 ,半数病人有上腹疼痛或不适。 9例FNH术前误诊为肝癌。 17例FNH有 14例为经典型 ,2例为毛细血管扩张型 ,1例为混合型。经典型FNH具有 4种特征性形态学改变 :即结节中央有星状瘢痕、异常结节状结构、畸形血管和毛细胆管增生。

cases of focal nodular heperplasia of the liver were studied with HE staining and immunohistochemistry. The patient population was composed of 12 males and 5 females, aged 13 to 71 years. The main symptom was abdomimal pain or discomfort. 9 patients were misdiagnosed as hepatic cell carcinoma (HCC) before operation. Histologically, 14 cases were of classical form, and 2 cases were of telangiectatic form, and 1 case mixed form. The classical form of FNH was defined by the presence of 4 characteristic histologic features: nodular central stellate scar, abnormal nodular architecture, malformed vessels, and cholangiolar proliferation. The causes of focal nodular hyperplasia of the liver were briefly discussed.