胃粘膜幽门螺旋菌感染发病学探讨——江苏省3013例胃粘膜病理组织学观察

Pathogenesis of Helicobacter Pylori Pathoepidemic Investigation on Gastric Biopsies of 3013 Cases in Jiangsu Province

从江苏省3013例胃粘膜病理组织学观察中发现幽门螺旋菌(HP)检出率为58.71%。它对胃粘膜有直接致病作用,可能是慢性活动性胃炎的病原,但不能提示它与胃癌有直接的病因学联系。50岁以下的男性、集体生活者可能为易感人群。宿主、环境因素在HP发病学中的作用值得重视。

Pathohistological observation on gastric biopsies from 3013 casesin Jiangsu Province showed that the infection rate of HelicobacterPylori (HP) was 58.71%. There were close relationship betweenquantity of this bacteria and infected deep as well as necrosis ofepithelia. There was evidence that HP was to be considered as atrue pathogen. The study confirmed the close association betweenHP and active chronic gastritis, but did not suggest the direct cor-relation between this organism and gastric cancer. Males under age of50, pergons within community contact seems the most likely infectedpopulation, Attention should be paid to the role of environmentand host in pathogenesis of HP.