二巯丙磺钠对抗四次甲基二砜四胺的致惊作用

Actions of sodium dimercaptopropanesulfonate against convulsions induced by tetraethylenedisulfotetramine

目的 探讨二巯丙磺钠对抗四次甲基二砜四胺急性中毒动物的致惊作用。方法 测定腹腔注射二巯丙磺钠后四次甲基二砜四胺 (TET)急性中毒小鼠的CD97和大鼠的死亡数 ;观察静脉注射二巯丙磺钠治疗后TET中毒家兔的行为变化 ;观察icv微量二巯丙磺钠后TET中毒大鼠的行为变化并描记脑电图。结果 外周给予二巯丙磺钠能有效抑制急性中毒动物的强直性惊厥 ,显著提高CD97,降低死亡数 ;中枢给予微量二巯丙磺钠也显著抑制大鼠的惊厥发作、降低死亡率和抑制脑电图中强直性惊厥波的出现。结论 二巯丙磺钠对TET急性中毒动物具有明显的抗惊厥作用。

OBJECTIVE:To study the actions of sodium dimercapt opropanesulfonate(DMPS) against convulsions induced by tetraethylenedisulfotetra mine(TET) in acutely poisoned animals.METHODS The 97% of con vulsant dose(CD 97) of TET poisoned mice were determined and the death numb er of TET poisoned rat was noted after ip administration of DMPS.The behavior o f TET poisoned rabbits was observed after iv administration of DMPS.The behavior and electroencephalogram (EEG) of TET poisoned rats were observed after intrac erebroventricular administration of traces of DMPS.RESULTS P eripheral administration of trace DMPS effectively inhibited tetanic convulsion and significantly elevated CD 97 and reduced the death number in acutely po isoned animals.Central administration of trace DMPS also significantly inhibited convulsive seizure,reduced the death number and inhibited the emergence of teta nic convulsion wave on EEG.CONCLUSION DMPS showed the marked anticonvulsive actions on acutely TET poisoned animals.