葛根黄酮载药系统表征

Investigation on characteristics of Radix Puerariae isoflavones-drug carriers

目的 测定葛根黄酮载药系统表征 ,据此检测乙基纤维素 /聚乙二醇 (EC/PEG)混合载体、PEG单一载体用固体分散技术 ,对葛根黄酮的分散作用。方法 用差示量热扫描 ,X 衍射分析、红外光谱及电子扫描显微镜照相等手段。结果 用固体分散技术 ,使葛根黄酮以均匀的状态分散在载药系统中 ,EC/PEG葛根黄酮固体分散体中 ,EC/PEG与葛根黄酮分子间相互作用 ,形成一种新的物相 ;PEG葛根黄酮固体分散体中 ,借分子中的·OH形成更多的氢键。EC/PEG葛根黄酮固体分散体释放12h后与释放前的形态显微图比较 ,相态变大变宽 ,且疏松。结论 固体分散技术对葛根黄酮有很好的分散作用。药物以分子尺度分散在载体中 ,PEG促进药物的释放 ,EC/PEG具有溶胀的作用。通过分析 ,EC/PEG葛根黄酮固体分散体为一理想的释药体系 ,先突释 ,后按零级动力学释药 ;PEG葛根黄酮固体分散体为一速释体系 ,上述分析手段为此提供了科学依据。

OBJECTIVE: To determine the characteristics of RP isoflavones in differens drug carrier system, including EC/PEG mixture carrier and PEG single carrier by solid dispersion technique. METHODS: DSC, X-ray diffraction, IR-spectra and SEM were used. RESULTS: By using solid dispersion technique, RP isoflavones was homogeneously dispersed in the drug carrier system. EC/PEG RP isoflavones solid dispersion formed a new type of material phase because of interaction between EC/PEG and RP isoflavones molecules. The PEG RP isoflavones solid dispersions formed more hydro-keys resulted by - OH in the molecules. After releasing 12 h, the EC/PEG RP isoflavones solid dispersion became much bigger, wider and soft than the material before releasing. CONCLUSION: RP isoflavones was dispersed in molecular size in the carrier. PEG was the hole-making agent improving the permeability to EC-membrane, and EC had the function of dissolution and inflation. It demonstrated that EC/PEG RP isoflavones solid dispersion was an ideal drug release system, which released fast at initial and then following zero-order mechanism; PEG RP isoflavones solid dispersion was a fast release system.