奥美拉唑不同途径、不同剂量给药抑制胃酸的效果

Effect of omeprazole on gastric acid inhibition in different dosage and drug giving ways

目的 :研究不同途径、不同剂量奥美拉唑抑制胃酸的效果 ,指导临床合理用药。方法 :将 10 0例内窥镜证实为活动期消化性溃疡病人分成A组 4 0例 ,静脉推注奥美拉唑 4 0mg ,bid ;B组 36例 ,口服奥美拉唑 2 0mg ,bid ;C组 2 4例 ,口服奥美拉唑 2 0mg ,qd。监测用药后d 3～ 5胃内 2 4hpH值变化 ,对A ,B 2组中各 10例 (为A2 ,B2 组 )测定了首次给药后的药物起效时间。结果 :A ,B组的抑酸效果相仿 (P >0 .0 5) ,胃内 pH值分别为 7.0 7±s0 .15和6 .9± 0 .6 ,与C组胃内 pH值 5.8± 1.4相比 ,差异有非常显著意义 (P <0 .0 1) ;A2 组起效时间为 (0 .7± 0 .6 )h ,B2 组为 (4.8± 1.0 )h ,差异有非常显著意义 (P <0 .0 1)。结论 :不同途径 3种剂量的奥美拉唑均有良好的抑酸效果 ,A ,B组更佳 ;

AIM:To study the effect of omeprazole on inhibiting intragastric acid in different dosage and drug giving ways and direct doctors to use the drug more correctly and reasonably. METHODS:One hundred patients with active peptic ulcer proved by endoscopy were divided into three groups.Forty patients of group A were treated with omeprazole 40 mg,iv,bid.Tirty six patients of group B were treated with omeprazole 20 mg, po ,bid.Twenty four patients of group C were treated with omeprazole 20 mg, po ,qd.Ten patients (A 2) in group A and 10 patients (B 2) in group B were monitored when administered the first dosage of omeprazole in order to get the earliest effective time of the drug.The intragastric pH of other 80 patients were monitored after administering omeprazole for 3 5 d. RESULTS:Twenty four hours intragastric pH detection after administering the drug for 3 5 d showed that the mean pH in group A was 7.07± s 0.15 and that in group B was 6.9±0.6,and there was no significant difference between the two groups,so their effects of gastric acid inhibition was similar( P >0.05),but greater than that of group C,5.8±1.4( P <0.01).The initial effective time after using the drug in group A 2 was (0.7± 0.6 ) h,and that in group B 2 was (4.8± 1.0 ) h.There was a significant difference between them( P < 0.01 ). CONCLUSION:All the three different dosages and drug giving ways of omeprazole have excellent effect on intragastric acid inhibition.But it is more rapidly to inhibit the gastric acid when omeprazole is used 40 mg intravenously twice a day.