局部亚低温对猪脑部温度梯度的影响

The effect of focal mild hypothermia on the temperature gradient in brain

目的 探讨局部亚低温对脑部温度梯度的影响 ,并探讨局部亚低温脑保护仪在治疗时间窗内将脑温降至亚低温水平的可能性。方法 采用医用半导体局部亚低温脑保护仪制冷器 ,温度分别为 10℃、6℃和 2℃ ,制冷的同时直接测量迪卡猪颅内不同部位的温度 ,建立猪脑三维空间温度梯度的数学模型。结果 (1)由数学模型推导出的理论值与实测值之间拟合良好 ,平均绝对误差为0 15℃。 (2 ) 2～ 10℃制冷可使壳核、丘脑温度在 17min内降至 32～ 34℃。结论 应用局部亚低温脑保护仪可在允许的时间窗内使脑温降至亚低温水平 ,并找出了制冷温度与脑温之间的函数关系 。

Objective Through studying the effect of focal mild hypothermia on the distribution of brain temperature, which reveals the function that the semi conductor refrigerator apparatus decreases the temperature to mild hypothermia level during therapeutic time window. Methods Directly measure the intracerebral temperatures of different regions when we refrigerator the brains of piglets. According to the results of the measure and the formula of heat conduction, we can establish the three dimensional space and the temperature gradient mathematical model of pig brain. Results (1) The theoretical data deduced by function model fit very well to the laboratory data, absolutely average error is 0.15℃. (2) After 17 minutes of the piglet refrigerated at 2～10℃, thalamic and putamen temperature decreases to 32～34℃. Conclusion Apply the regional semi conductor refrigerator apparatus to decrease the brain temperature to mild hypothermia level during therapeutic time window and find the function relationship between refrigerator temperature and brain temperatures so as to provide the theoretical proof for clinical application of focal mild hypothermia.