甲孕酮/甲地孕酮在鼻咽癌放、化疗中的临床应用

The clinical application of MPA/MA in the patients with NPC treated with CT+RT

目的 评价甲孕酮 /甲地孕酮在Ⅱ～Ⅲ期的鼻咽癌患者放、化疗中保护骨髓、减少消化道反应以及改善患者生活质量的作用。方法 治疗组 (3 7例 )采用DF/CADB1e方案诱导化疗 +常规放疗 +甲孕酮 /甲地孕酮 (50 0mg/ 1 60mg/d) ;对照组 (4 5例 )为单纯DF/CADB1e方案诱导化疗 +常规放疗。两组的毒副反应发生率按WHO急性和亚急性毒性反应标准进行评价 ;患者的生活质量则根据临床受益反应 (ClinicalBenefitResponse)加以评价。 结果 在血液学毒性和消化道反应的发生率方面 ,治疗组低于对照组 (P <0 0 5) ;就提高患者生活质量来看 ,治疗组明显高于对照组 (P <0 0 1 )。治疗组未见甲孕酮 /甲地孕酮所致的严重毒副反应。结论 甲孕酮 /甲地孕酮对接受放化疗的鼻咽癌患者在保护骨髓、减轻消化道反应和提高生活质量等方面具有明显的作用。

Objective To evaluate the effect of MPA (medroxyprogesterone acetate)/MA(megestrol acetate)in protectiong marrow、decreasing digestive tract by effect and improving the quality of life in the patients with NPC(nasopharygeal cancer)stageⅡ～Ⅲ treated with CT(chemotherapy)+RT(radiotherapy).Methods 37 cases in treatment group were treated with CT+RT+MPA/MA(500mg/160mg/d)and 45 cases in control group were treated with CT+RT.Cytotoxic reactions were assessed by the grading of acute and subacute toxicity(WHO criteria).The quality of life in the patients was evaluated by clinical benefit response.Results The rate of hematologic and digestive tract toxicity is lower in treatment group than in control group( P <0 05).The quality of life is better in treatment group than in control group( P <0 01).The serious side effect of MPA/MA didn't appear in the patients in treatment group.Conclusion MPA/MA has remarkable effect in protecting marrow、decreasing digestive tract by effect and improving the quality of life in the patients with NPC treated with CT+RT.