摘要
目的 探讨慢性乙型肝炎患者肝组织中FasL表达与血清可溶性FasL水平的关系。方法 用免疫组化方法检测 60例慢性乙型肝炎患者肝穿组织FasL的表达 ,同时用酶联免疫吸附试验检测血清可溶性FasL。结果 重度慢性乙型肝炎患者血清中sFasL水平 >中度 >轻度 ,各组间差异有显著意义 (P <0 0 1 ) ;慢性乙型肝炎患者肝组织FasL表达的程度和血清sFasL水平与肝组织病变的活动性一致。结论 (1 )肝组织炎症程度加重 ,肝组织FasL抗原的表达增强 ,同时血清中sFasL水平升高 ;(2 )Fas介导的肝细胞凋亡在慢性乙型肝炎的发病机制中起重要作用 。
Objective To explore the relationship between the expression of FasL and serum levels of soluble fasL in patients with chronic hepatitis B.Methods liver biopsies were studied by immunohistochemistry to determine FasL and serum levels of soluble FasL(sFasL)were detected with ELISA in 60 patients with chronic hepatitis B.Results sFasL levels in patients with chronic hepatitis B were severe>moderate>mild, there was significant difference among the three groops ( P <0 01),the histological activity index was correlated with the degree of expression of fasL and the serum levels of sFasL( P <0 01).Conclusion (1)There was a correlationship betweem the expression of FasL antigen in liver tissue、the serum sFasL levels and histological activity;(2) The hepatic apotosis mediated through Fas antigen may play an important role in pathogenesis of chronic hepatitis B, decreasing Fas expression contribute to alleviate the degree of hepatic injury.
出处
《重庆医学》
CAS
CSCD
2001年第6期528-529,共2页
Chongqing medicine
基金
福建省漳州市科委基金资助项目 (Z0 0 2 7)
