测定烟酸类药物的全固态漆酚树脂传感器研究

Study on an All-solid-state Acidum Nicotincum Sensor

研制了一种新型的漆酚树脂为载体的全固态电位型传感器 ,用以测定烟酸类药物。其Nernst线性响应范围为 1 .0× 1 0 -2 ～ 6 .0× 1 0 -6 mol/ L,斜率为 5 7.0 ,检测限为 2 .5× 1 0 -6 mol/ L。此传感器响应迅速 ,重现性好 ,稳定性好 ,用此传感器测定烟酸类药物的含量 ,结果与药典法相符。

A new all-solid-state acidum nicotinicum chemical sensor was developed. This sensor showed Nernst response for acidum nicotinicum with a slope of 57.0 over the concentration range of 1.0×10 -2 ~6.0×10 -6 mol/L. The detection limit was 2.5×10 -6 mol/L. This senser had fast response and good reproducibility and good stability. It was used for the detemination of acidum nicotinicum in medicinal tablet by the standard curve method. The process of this method are simple and the result obtained accords with those of pharmacopoeia.