硒催化法合成2-吡啶脲的研究

Studies on Selenium-Catalyzed Synthesis of 2-Pyridylurea

采用硒催化的一氧化碳还原羰基化法 ,由硝基苯衍生物与 2 氨基吡啶进行反应 ,得到的不是比例相当的三种脲类物质混合物 ,而主要得到非对称的吡啶脲 .进一步发展了硒 /一氧化碳催化体系对硝基化合物的还原羰基化法 ,可望用来合成一系列含取代基的苯基吡啶基脲类物质 ;该合成方法工艺简单 ,操作易行 .对部分产物进行了红外光谱、核磁共振谱、高压液相色谱及元素分析等鉴定 .

Nitrobenzene and its derivatives can react with 2-aminopyridine as coreagent by using the method of selenium-catalyzed CO reductive carbonylation. Partial products were identified by IR, 1H NMR, 13 C NMR, HPLC and element analysis. The obtained products are not three kinds of ureas that are almost equal in amount, but are mainly unsymmetrical pyridylureas. The reductive carbonylation of nitro compounds with primary amines as coreagents has been developed by using the catalytic system of Se/CO. This synthetic method can be expected to synthesize a series of phenyl pyridylureas containing substituting group on the benzene ring. It is indicated that the synthetic method is simple and also very easy to operate. At present, the method to synthesize these compounds has not been found in the literature.