异噁唑啉基咪唑 [1,2-a]吡啶C-核苷类化合物的合成(英文)

Synthesis of Novel Isoxazolinyl Substituted Imidazo [1,2-a] pyridine C-nucleoside Analogs

以异口恶唑啉基环取代呋喃核糖环 (ribosering)为基本单元 ,成功地合成了一系列咪唑 [1 ,2 a]吡啶衍生物的C 核苷化合物 3和 4(其中碱基和异口恶唑啉基环之间以C -C化学键方式连接 )。这两种异构体中N和O原子处于相互交换的位置 。

Isoxazoline rings have been successfully connected to imidazopyridine derivatives via carbon carbon bonds for the synthesis of new C nucleoside analogs 3 and 4. These two isomers, that possess the altered positions of nitrogen and oxygen atoms, can be formed through dipolar cycload dition reactions of the appropriate olefins and nitrile oxides.