模拟酶微型反应器中糠醛催化氧化为糠酸

Synthesis of Furoic Acid by Catalytic Oxidation of Furfural in the Mimic Enzyme Microreator

在水与有机试剂组成的非均相体系中 ,用 β 环糊精 (β cyclodextrin ,缩写 :β CD)衍生物模拟生物酶 ,以强力搅拌下分散在有机溶剂中的小水珠作为微型反应器进行糠醛催化氧化为糠酸的反应 ,停止搅拌后体系立即分层 ,产物在有机相 ,残留的原料和模拟酶在水相。本合成方法简单 ,溶剂和模拟酶能回收 ,不产生污染 ,催化效率较均相高 ,为绿色合成化学制备医药。

Furoic acid was synthesied by catalytic oxidation in the mimic enzyme microreactor, which was constructed by strong stirring a non homogeneous phase system of organic reagent and water using β cyclodextrin derivative as an imitating enzyme. This method is easy to handle and more effective than the corresponding reaction in homogeneous phase. After reaction the product, raw material and mimic enzyme were in different layers and can be easily seperated, both the solvent and the enzyme can be retrieved, not giving rise to pollutions and proving a kind of new synthetic system.