新型甲酰胺基噻唑C-核苷类化合物的结构分析和设计(英文)

Analysis and Design on the Structures of Novel Tiazofurin C-nucleoside Analogues

着重对具有抗癌活性的甲酰胺基噻唑 C-核苷 (Tiazofurin)类化合物的分子结构特点作了系列分析 ,提出以异口恶唑烷 (啉 )基环取代现有呋喃核糖环合成新型抗病毒活性的甲酰胺基噻唑

Efforts have been made in analysis of structural modification of Tiazofurin C\|nucleoside analogues and in attempting to find the structure\|activity relationship of those analogs.To find high antitumor activty C\|nucleosides,one class of Tiazofurin C\|nucleoside analogues in which the ribofuranosyl sugar is replaced by novel isoxazolidinyl (isoxazolinyl) rings has been designed.Some reasonable synthesis schemes have been considered.