5-碘水杨酸的合成

Synthesis of 2 - Hydroxy - 5 - Iodobenzoic Acid

以水杨酸和一氯化碘为原料,考察了溶剂体系、反应温度以及原料配比对反应结果的影响,得到优化的反应条件。最佳反应条件为:反应溶剂为水、反应温度为45～50℃、水杨酸与一氯化碘摩尔比为1.0:1.0,粗品精制后收率达73％,纯度不低于99％。

2 - Hydroxy - 5 - iodobenzoic acid was synthesized from 2 - hydroxybenzoic acid and iodine monochlo-ride . Effects of solvent, reaction temperature and molar ratio of 2 - hydroxybenzoic acid to iodine monochloride on reaction were discussed. The optimum conditions were as follows: water as reaction solvent, reaction temperature of 45 - 50 ℃, molar ratio of 2 - hydroxybenzoic acid to iodine monochloride at 1.0:1.0. The yield was up to 73 % and the purity was more than 99% after refining.