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蛋白激酶CK2 被引量:7

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摘要 蛋白激酶 CK2是一种高度保守的真核细胞中普遍存在的信使非依赖性丝氨酸 /苏氨酸蛋白激酶。它是由两个催化亚基 (α和 /或 α′)和两个调节亚基 β构成的不均一四聚体。其基本结构。
出处 《国外医学(分子生物学分册)》 CSCD 2001年第4期206-209,共4页
基金 广东省卫生厅科研基金 (A2 0 0 0 4 87) 广东医学院标志性成果扶持项目 (XK0 0 0 2 )资助
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同被引文献105

  • 1郭予琦,田曾元.玉米转录因子Opaque-2的分子生物学特性[J].种子,2006,25(4):45-47. 被引量:2
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  • 4LIU W,XU ZH H, LUO D,XUE H W. OsCKIl,a rice casein kinase I ,plays significant role in auxin related root development and functions of plant hormones[J]. Plant J. ,2003,36: 189-202.
  • 5DUNCAN J S, LITCHFIELD D W. Too much of a good thing:The role of protein kinase CK2 in tumorigenesis and prospects for therapeu tic inhibition of CK2[J]. Biochimi. Biophy. Acta,2008,1 784(1) :33--47.
  • 6SINGH N N,RAMJI D P. Protein kinase CK2,an important regulator of the inflammatory reponse? [J]. J. Mol. Med. ,2008,86(8) :887 --897.
  • 7ISHII A, NONAKA T, TANIGUCHI S, SAOTO T, ARAI T, MANN D, IWATSUBO T, HISANAQA S,GOEDERT M, HASEQAWA M. Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha synuelein: Implication for alpha-synueleinopathies[J]. FEBS Lett,2007,581(24) :4 711--4 717.
  • 8PADMANABHA R,GLOVER C V. Casein kinase II of yeast contains tow distinct alpha polypeptides and an unusually large beta subunit [J]. J. Biol. Chem. ,1987,262(4) :1 829--1 835.
  • 9MEGGIO F,BOLDYREFF B, MARCHIORI F,PERICH J W,ISSINGER O G,PINNA L A. The effect of polylysine on casein-kinase-2 activity is influenced by both the structure of the prutein/peptide substrates and the subunit composition of the enzyme[J]. Eur. J. Biochem. ,1992,205(3) :939--945.
  • 10LITCHFIELD D W. Protein kinase CK2: structure, regulation and role in cellulardecisions of life and death[J]. Biochem. J. , 2003,369 (Pt1):1--15.

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