TGF-β在骨关节炎发生中的可能作用

The Probable Mechanism of TGF-beta Involving in Osteoarthritis

转化生长因子TGF - β具有广泛的生理效应 ,对于维持关节软骨正常有重要意义。软骨细胞外基质降解和关节软骨损坏是骨关节炎的重要特征 ,研究表明TGF - β一方面通过调节细胞外基质成分含量维持基质的正常更新 ,另一方面通过调节关节软骨细胞的形成、增殖和分化来保持正常数量和正常生理状态的软骨细胞。本文就这两个方面综述了最新研究进展 ,以探讨TGF - β在骨关节炎发生中的可能调节机制。

Transforming growth factor beta (TGF beta) have broad physiological effects, it plays an important role in maintaining articular cartilage.Degrading of articular cartilage extracellular matrix and lossing of cartilage are important characteristics of osteoarthritis, research evidences show that TGF beta can regulate the homeostasis of extracellular matrix, and, forming, proliferation and differentiation of chondrocyte, thus, to remain enough content of normal chondrocyte in articular cartilage.This review focuses primarily on advances in these field and discussing the probable mechanisms of TGF beta involving in Osteoarthritis.\;