SLE患者TNFB-2等位基因频率分析

Analysis of Frequency of TNF?B-2 Allele in SLE Patients

目的 检测系统性红斑狼疮（SLE）患者肿瘤坏死因子（TNF B－2）等位基因频率，寻找SLE的易感基因。方法 采用聚合酶链式反应－限制性片段长度多态性（PCR－RFLP）分析法。结果 SLE患者TNF B－2等位基因频率比正常显著增高（P＜0．01）。结论 TNF B－2等位基因可能是SLE的易感基因或易感基因的标记基因。

Objective To detect the frequency of TNF?B 2 allele and find susceptible gene in SLE patients. Methods Using the polymerase chain reaction restriction fragment length polymorphism (PCR RFLP).Results The frequency of TNF?B 2 allele in SLE patients was significantly higher than that in controls (P<0.01).Conclusion The TNF?B 2 allele might be a susceptible gene of SLE or a marker gene of the susceptible gene.