肿瘤基因治疗技术
被引量：2
Gene Therapy Technique
摘要
肿瘤基因治疗就是将一段特定的遗传信息物质DNA或RNA通过人工方法导入肿瘤细胞以治疗肿瘤性疾病。目前的研究主要包括三个方面 :肿瘤免疫基因治疗、反义RNA、三链DNA。其中研究较多的是肿瘤免疫基因治疗。本文主要对肿瘤免疫基因治疗的构建、接种、应用等方面做了综述 ,并简要介绍了反义RNA和三链DNA技术。
出处
《中国肿瘤》
CAS
2001年第10期577-579,共3页
China Cancer
参考文献14
-
1[1]Tanghe A, Lefevre P, Denis O, et al. Immunogenicity and protective efficacy of tuberculosis DNA vaccines encoding putative phosphate transport receptors [J].J Immunol,1999,162(2):1113－ 1119.
-
2[2]Montgomery DL,Shiver JW,Leander KR,et al.Heterolog_ ous and homologous protection against influenza A by DNA vaccination: optimization of DNA vectors [J].DNA and Cell Biology,1993,12(9):777－ 783.
-
3[3]Gil Castro A,Silva RA,Appelberg R.Endogenously produced IL_2 is required for the induction of protective T cells during mycobacterium avium infections in mice [J]. The Journal of Immunology,1995,155(4):2013－ 2019.
-
4[4]Lai WC,Bennett N.DNA vaccines [J].Critical Reviews in Immunology,1998,18(5):449－ 484.
-
5[5]Gramzinski RA,Millan CL,Obaldia N.Immune response to a hepatitis B DNA vaccine in aotus monkeys: a comparison of vaccine formulation,route,and method of administration [J].Mol Med,1998,4(2):109－ 118.
-
6[6]Schirmbeck R,Boehm W,Ando K,et al.Nucleic acid vaccination primes hepatitis B virus surface antigen_specific cytotoxic T lymphocytes in nonresponder mice [J].J Virol,1995,69(10):5929－ 5934.
-
7[7]Davis HL.Plasmid DNA expression systems for the purpose of immunization [J].Current Opinion in Biotechnology,1997,8(5):635－ 640.
-
8[8]Tuting T,Wilson CC,Martin DM,et al.Autologous human monocyte_derived dendritic cells genetically modified to express melanoma antigens elicit primary cytotoxic T cell responses in vitro: Enhancement by cotransfection of genes encoding the Th1_biasing cytokines IL_12 and IFN_alpha [J].J Immunol,1998,160(3):1139－ 1147.
-
9[9]Ho TY,Hsiang CY,Hsiang CH,et al.DNA vaccination induces a long_term antibody response and protective immunity against pseudorabies virus in mice [J].Arch Virol,1998,143(1):115－ 125.
-
10[10]Wolff JA,Dowty ME,Jiao S,et al.Expression of naked plasmids by cultured myotubes and entry of plasmids into T tubules and caveolae of mammalian skeletal muscle [J].J Cell Sci,1992,103(4):1249－ 1259.
同被引文献15
-
1JunDou,GuobinChen,JingWangt,FengshuZhao,JunsongChen,XuesongFang,QuanTang,LiliChu.Preliminary Study on Mouse Interleukin-21 Application in Tumor Gene Therapy[J].Cellular & Molecular Immunology,2004,1(6):461-466. 被引量：14
-
2冯学胜,郑仲承,汤钊猷,戈凯,王立群,薛琼,孙兰英,刘新垣.逆转录病毒介导的人TNF在人肝癌细胞系(SMMC)中的表达[J].中华微生物学和免疫学杂志,1996,16(1):33-36. 被引量：5
-
3Anderson SC,,Johson DE,Harris MP, et al.p53 gene therapy in a rat model of hepatocellular carcinoma: intra-arterial delivery of a recombinant adenovirus[].Clio Cancer Rcs.1998
-
4McMasters RA,Saylors RL,Jones KE,et al.Lack of bystander killing in herpes simplex virus thymidine kinase-transduced colon cell lines due to deficient connexin43 gap junction formation[].Human Gene Therapy.1998
-
5Kianmanesh AR,Perrin H,Panis Y,et al.A "distant" bystander effect of suicide gene therapy: regression of nontransduced tumors together with a distant transduced tumor[].Human Gene Therapy.1997
-
6Ido A,Nakata K,Kato Y,et al.Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human alpha-fetoprotein gene promoter[].Cancer Research.1995
-
7Kanai F,Lan KH,Shiratori Y,et al.In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene[].Cancer Research.1997
-
8Klinman D M,Yamshchikov G,Ishigatsubo Y.Contribution of CpG motifs to the immunogenicity of DNA vaccines[].Journal of Immunology.1997
-
9Yi AK,Tuetken R,Redford T,et al.CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species[].The Journal of Immunology.1998
-
10Kim J H,Gong S J,Yoo N C,et al.Effects of interleukin-2 transduction on the human hepatoma cell lines using retroviral vector[].Oncology Reports.1999
引证文献2
-
1洪晓武,窦骏,赵枫姝,陈峻崧,陈国兵,张爱凤.GM-CSF基因免疫治疗小鼠骨髓瘤的实验研究[J].东南大学学报（医学版）,2006,25(4):244-247.
-
2左朝晖,谌忠友.肝癌基因治疗的进展[J].中国医学文摘（肿瘤学）,2002,16(2):182-184. 被引量：1
-
1田长海,李祺福,欧阳高亮,洪水根.肿瘤反基因治疗研究进展[J].国外医学（肿瘤学分册）,2001,28(4):274-276. 被引量：3
-
2张昌菊.肿瘤免疫基因治疗[J].实用医学进修杂志,1995,23(4):247-249.
-
3雷小勇,张洹.从反义技术到反基因技术:基因治疗的新突破[J].医学与哲学,2001,22(9):10-12.
-
4方玲妹,孔海深.血清cf-DNA定量分析在宫颈癌早期辅助诊断及预后判断中的价值[J].健康研究,2016,36(6):702-704. 被引量：1
-
5郭宁.基因转移及其诱导的肿瘤细胞凋亡[J].国外医学（免疫学分册）,1998,21(1):30-32.
-
6黄洁.癌基因、抑癌基因与卵巢癌基因治疗[J].国外医学（妇产科学分册）,1998,25(4):205-209. 被引量：1
-
7汪洋,宫琳琳,邵淑娟.实时荧光定量PCR在肿瘤研究中的应用[J].肿瘤,2004,24(2):196-197. 被引量：14
-
8刘复兴.肿瘤免疫基因治疗及其进展[J].咸宁医学院学报,2002,16(4):300-302.
-
9张国华,戚菁,施维,王志伟,景荣荣,吴信华,申娴娟,鞠少卿.游离DNA检测对结直肠癌诊断价值的研究[J].临床检验杂志,2012,30(11):894-895. 被引量：3
-
10贺艳,王水良,孙树汉.肿瘤基因治疗研究若干新进展[J].第二军医大学学报,2002,23(11):1258-1260.
