PD-ECGF在宫颈癌中的表达及与新生血管的关系

Expression of Platelet-derived Endothelial Cell Growth Factor in Cervical Cancers and its Relationship to Angiogenesis

[目的]探讨宫颈癌中血小板源内皮细胞生长因子 (PD ECGF)表达与新生血管形成的关系。[方法]用免疫组化技术检测45例宫颈癌实质细胞和间质细胞中PD ECGF的表达和微血管计数(MVC)。[结果]鳞癌癌细胞中PD ECGF表达明显高于腺癌 ,其表达率分别为82.4 %和17.6 % ,二者比较差异显著 (P<0.01) ;腺癌间质细胞PD ECGF阳性率明显高于鳞癌 ,分别为72.7%和11.8 % ,二者比较具有显著性差异 (P<0.01)。间质细胞中PD ECGF阳性表达与高MVC值、3年和5年存活率均有显著相关性。[结论]间质细胞中PD ECGF具有更强的促血管生成作用 。

To observe the expression of platelet derived endothelial cell growth factor (PD ECGF) separately in stroma cells,and in cancer cells, and its relationship to the angiogenesis. Expression of PD ECGF in cancer cells and in stroma cells with microvessal count(MVC) were studied by immunohistochemical technology. Immunopositivity for PD ECGF in stroma cells was significantly higher in cervical adenocarinoma(CAC) than that in cervical squamous cell carcinoma(CSC) (P<0.01). Expression of PD ECGF in cancer cells was significantly higher in CSC than that in CAC (P<0.01). High MVC was closely correlated with positive PD ECGF expression in stroma cells (P<0.05).The survival rate in patients with positive PD ECGF expression in stroma cells was significantly lower than those with positive PD ECGF expression in cancer cells (P<0.01). [Conclusions]The expression of PD ECGF in stroma cells may play a crucial role in the promotion of angiogenesis, we propose that angiogenic factors may be different in various types of cervical cancers.