低分子量肝素的制备及其结构与活性差异(英文)

Preparation and Structure-Activity Differences of Low Molecular Weight Heparins (LMWH)

低分子肝素作为一种抗血栓的多糖药物在临床中已应用了二十多年 ,目前已作为外科预防血栓形成药物 ,并在治疗急性静脉栓塞紊乱方面取代了未分级肝素。因肝素的来源和制备的方法不同使低分子肝素的精细结构不同 ,低分子肝素结构的复杂性 ,使得各产品的生物活性 ,例如抗蛋白酶活性不同 ,从而导致其临床使用的标准不同。

As a polysaccharide drug, low molecular weight h eparins (LMWH) which were introduced as antithrombotic agents about twenty years ago, are now established as surgical thromboprophylaxia drugs and replacing unf ractionated heparin (UFH) in the acute treatment of venous thromboemblic disorde rs. The precise structure of heparin varied with the sources and the preparation methods. The complex structure made the biological activities, for example, ant iprotease activity different from each LMWH products, and led to the clinical us age standard different. The production methods,the structure difference and als o the antiprotease activity of eight commercial LMWH products were introduced in this paper.