摘要
目的 :观察双草退黄冲剂 1号治疗急性黄疸型肝炎深度黄疸患者的临床疗效并探讨其作用机理。方法 :对 34例急性黄疸型肝炎深度黄疸患者 (治疗组 )在西医常规治疗的基础上加用口服双草退黄冲剂 1号治疗 4周 ,分析其黄疸消退情况及疗效等 ,与同期西医常规治疗 2 2例 (对照组 )作比较。并通过动物实验观察其对小鼠D 半乳糖胺急性肝损伤、肝脏超氧化物歧化酶 (SOD)及血清丙氨酸转氨酶 (ALT)、天冬氨酸转氨酶 (AST)的影响。结果 :治疗组显效率和有效率分别为 73 5 % (2 5 / 34例 )和 2 3 5 % (8/ 34例 ) ,对照组为 5 9 1% (13/ 2 2例 )和 4 0 9% (9/ 2 2例 ) ,两组显效率比较差异有显著性 (P <0 0 5 ) ;实验研究显示双草退黄冲剂 1号大、中剂量组肝损伤轻微 ,疗效明显优于模型组 ,且使肝脏SOD活性升高及血清ALT、AST降低 (P <0 0 5 ,P <0 0 1)。结论 :双草退黄冲剂 1号可加快黄疸消退、改善肝功能及减轻肝损伤 ,其机理可能与提高SOD活性 。
Objective: To observe the effect of Shuangcao Tuihuang Granule 1 (SCTH 1) in treating severe jaundice of acute icterohepatitis and to study its mechanism. Methods: Thirty four patients with severe jaundice of acute icterohepatitis were treated with SCTH 1, their therapeutic effects were analyzed. In the experimental studies, the influences of SCTH 1 on acute liver injury, liver superoxide dismutase (SOD) and serum ALT and AST were monitored. Results: The markedly effective rate and effective rate of the treated group were 73.5% and 23.5% respectively. The markedly effective rate of the treated group was obviously higher than that of the control group (P<0 05). Experimental study revealed that SCTH 1 could reduce the level of serum transaminase and inflammation of liver tissue in mice with acute liver damage. In addition, SCTH 1 could raise the activity of liver SOD (P<0 05). Conclusion: SCTH 1 could accelerate the jaundice subsidence, improve the liver function and ameliorate the liver injury, its mechanism was possibly correlated with raising SOD activity, scavenging the oxygen free radicals.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2001年第9期649-651,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
广东省科委攻关项目 (No .970 2 7)