双草退黄冲剂1号治疗急性黄疸型肝炎深度黄疸的临床与实验研究

Clinical and Experimental Study of Shuangcao Tuihuang Granule-1 in Treating Severe Jaundice of Acute Icterohepatitis

目的 :观察双草退黄冲剂 1号治疗急性黄疸型肝炎深度黄疸患者的临床疗效并探讨其作用机理。方法 :对 34例急性黄疸型肝炎深度黄疸患者 (治疗组 )在西医常规治疗的基础上加用口服双草退黄冲剂 1号治疗 4周 ,分析其黄疸消退情况及疗效等 ,与同期西医常规治疗 2 2例 (对照组 )作比较。并通过动物实验观察其对小鼠D 半乳糖胺急性肝损伤、肝脏超氧化物歧化酶 (SOD)及血清丙氨酸转氨酶 (ALT)、天冬氨酸转氨酶 (AST)的影响。结果 :治疗组显效率和有效率分别为 73 5 % (2 5 / 34例 )和 2 3 5 % (8/ 34例 ) ,对照组为 5 9 1% (13/ 2 2例 )和 4 0 9% (9/ 2 2例 ) ,两组显效率比较差异有显著性 (P <0 0 5 ) ;实验研究显示双草退黄冲剂 1号大、中剂量组肝损伤轻微 ,疗效明显优于模型组 ,且使肝脏SOD活性升高及血清ALT、AST降低 (P <0 0 5 ,P <0 0 1)。结论 :双草退黄冲剂 1号可加快黄疸消退、改善肝功能及减轻肝损伤 ,其机理可能与提高SOD活性 。

Objective: To observe the effect of Shuangcao Tuihuang Granule 1 (SCTH 1) in treating severe jaundice of acute icterohepatitis and to study its mechanism. Methods: Thirty four patients with severe jaundice of acute icterohepatitis were treated with SCTH 1, their therapeutic effects were analyzed. In the experimental studies, the influences of SCTH 1 on acute liver injury, liver superoxide dismutase (SOD) and serum ALT and AST were monitored. Results: The markedly effective rate and effective rate of the treated group were 73.5% and 23.5% respectively. The markedly effective rate of the treated group was obviously higher than that of the control group (P<0 05). Experimental study revealed that SCTH 1 could reduce the level of serum transaminase and inflammation of liver tissue in mice with acute liver damage. In addition, SCTH 1 could raise the activity of liver SOD (P<0 05). Conclusion: SCTH 1 could accelerate the jaundice subsidence, improve the liver function and ameliorate the liver injury, its mechanism was possibly correlated with raising SOD activity, scavenging the oxygen free radicals.