摘要
目的 对黄体酮微球的制备和体外释药进行研究。方法 阴离子聚合法合成聚谷氨酸苄酯 -谷氨酸甲酯共聚物 (PBMG) ,溶剂挥发法制备 PBMG为载体的微球并考察了黄体酮微球的释药特性。结果 油水相之比 ,乳化速度和乳化时间是影响粒径大小的主要因素。聚合物组成和释药介质均影响药物微球的释药速率。结论
AIM\ The purpose is to investigate the preparation and drug rele ase of progester one loaded microspheres based on poly(γ-benzyl glutamate - methyl glutamate) (PBMG). METHODS\ PBMG copolymers were synthesized by anionic polymeriz ation. Progesterone loaded microspheres based on PBMG were prepared by solvent e vaporation method. The progesterone release behavior from microspheres \%in vitr o\% was determined. RESULTS\ The ratio of O/W phase volume, emulsification rate and emulsification time were the important factors affecting the microsphe re size. The different components carriers and dissolution medium also had the effect on the release kinetics of microspheres \%in vitro\%. CONCLUSION\ The progesterone loaded PBMG microspheres can be sustained-release.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2001年第4期253-256,共4页
Journal of China Pharmaceutical University