慢性病毒性肝炎合并巨细胞病毒感染分析

Analysis in patients with chronic viral hepatitis co-infected with cytomegalovirus

[目的 ]探讨慢性病毒性肝炎合并巨细胞病毒感染对肝功能及病毒复制的影响 .[方法 ]分别检测了 3 2例慢性病毒性肝炎患者抗 巨细胞病毒IgM、乙型肝炎病毒血清学标志、抗 丙型病毒性肝炎抗体及生物化学指标 ;另选择 2 0例健康人 ,检测其抗 巨细胞病毒IgM ,与慢性病毒性肝炎患者的作对照 .[结果 ]慢性乙型肝炎病例中抗 巨细胞病毒IgM阳性率为 4 1% ,慢性丙型肝炎病例中抗 巨细胞病毒IgM阳性率为 4 0 % .血清抗 巨细胞病毒IgM阳性的慢性肝炎患者总胆红素、谷丙转氨酶水平及肝功能复常天数均明显升高或延长 ,并伴有发热、呕吐、黄疸、肝大症状或体征的加重 .[结论 ]巨细胞病毒感染好发于免疫虚损的宿主 ,又可抑制宿主免疫功能 ,有利于病毒复制 .合并巨细胞病毒感染可加重肝功能障碍 .

OBJECTIVE?To investigate the effects of liver function and hepatitis B virus (HBV) replication in patients with chronic viral hepatitis co-infected with cytomegalovirus. ?METHODS?It was detected from sera in 32 cases with chronic viral hepatitis that the anti-cytomegalovirus IgM, anti-hepatitis C virus(HCV) antibodies, sera sign of HBV and biochemical parameters. Contral sera taken from twenty normal persons were tested for cytomegalovirus IgM antibodies.?RESULTS?The positive rate of anti-cytomegalovirus IgM in the patients with chronic hepatitis C was 40%. Levels of total bilirubin and alanine aminotransferase in the positive cases of anti-cytomegalovirus IgM were higher than that in the negative cases of anti-cytomegalovirus IgM, and their convalescences of liver function were longer, accompanying with the aggravation of fever, vomit, jaundice and hepatomegaly. ?CONCLUSION? The cytomegalovirus infection predispose in the immunocompromised host and depress the host's immune functions as well, which is in favour replication of hepatitis B virus. The patient's liver dysfunction was deteriorated by cytomegalovirus co-infection.