应用漱口液对根治幽门螺杆菌的疗效

The Effect of Mouthrinse Solution on the Eradication of Helicobacter Pylori

目的 :了解漱口液根除口腔内幽门螺杆菌的疗效。方法 :98例胃粘膜幽门螺杆菌阳性的患者随机分为两组 ,A组与B组。两组幽门螺杆菌阳性率相同。两组均采用奥美拉唑、阿莫西林和甲硝唑口服 ,A组另以漱口液 (阿莫西林、甲硝唑 )漱口 ,每日 3次 ,治疗 2周。治疗前后均取牙菌斑、唾液及胃粘膜标本作幽门螺杆菌培养。结果 :A组胃粘膜标本治疗前 5 1例阳性 ,治疗后仅 3例阳性 ,口腔HP治疗前 2 3例阳性 ,治疗后 3例阳性。B组胃粘膜标本治疗前 4 7阳性 ,治疗后仅 2例阳性 ,口腔HP治疗前 2 1例阳性 ,治疗后 18例阳性。胃粘膜HP转阴率两组之间无显著差异 (p >0 0 5 ) ,而口腔HP转阴率两组之间有极为显著的差异 (p<0 0 0 1)。结论 :采用漱口液治疗口腔中幽门螺杆菌可能具有根治幽门螺杆菌的作用。

Objective:to evaluate the effect of mouthrinse solution for the eradication of helicobacter pylori.Methods:98 patients with gastric helicobacter pylori positive were randomly devided into two groups,the group A and the group B.The two groups were treated by Omeprazole,amoxicillin and metronidazole,and the group A was also treated by mouthrinse solution containing amoxicillin and metronidazole.Results:There was no significant difference of gastric HP eradication rate between group A and B(p>0 05),the oral HP eradication rate was significant between group A and B(p<0 001).Conclusion:Mouthrinse solution for the treatment of oral HP infection is a useful method for the clearance of oral HP,and may be the best way for eradication of Helicobacter pylori infection.