结肠癌危险因素的病例对照研究

A Case-Control Study of Risk Factors of Colon Cancer

目的:研究结肠癌的危险因素,为监测和控制嘉善县结肠癌提供依据。方法:实施基于全人群的病例对照研究;以统一的调查表调查151例结肠癌病人和1540名健康对照者;应用STATA5.0软件包进行单因素、多因素非条件Logistic回归分析。结果:与结肠癌发病有关的主要危险因素有下消化道疾病史(OR=3.910),一级亲属结肠直肠癌病史(OR=3.298),心理情绪不佳(OR=2.224),饮酒(OR=1.721)及职员职业(OR=3.068);保护因素有10年前蔬菜月均消耗量高(OR=0.774),使用冰箱(OR=0.442)及10年前人均月收入低(OR=0.725)。结论:下消化道疾病、一级亲属结直肠癌病史及心理情绪不良是结肠癌危险因素,蔬菜是预防结肠癌的保护因素。

Objective: To investigate the risk factors of colon cancer in order to monitor and control colon cancer in Jiashan. Methods: A population-based case-control study was conducted. One hundred and fifty-one cases of colon cancer and 1540 healthy controls were interviewed with uniformed questionnaires. Non-conditional Logistic regression was used for univariate and multivariate analyses. Results: Main variates related to the genesis of colon cancer were lower digestive tract diseases (Odds Ratio,OR=3.910), history of colorectal cancer of first degree relatives (OR=3.298), psychological depression (OR=2.224), alcohol consumption (OR=1.721), and white collar clerks (OR=3.068). High monthly vegetable intake 10 years ago (OR=0.774), refrigerator usage (OR=0.442) and low monthly income 10 years ago (OR=0.725) showed protective effects on colon cancer. Conclusion: Lower digestive tract diseases, colorectal cancer history of first degree relatives and psychological depression are colon cancer risk factors. Intaking more vegttables is the protect factor of colon cancer.