摘要
目的 :探讨睡眠与免疫的关系。方法 :将SD大鼠 2 2只随机分为睡眠剥夺组和对照组各 11只 ,采用免疫学方法分别观察了脾细胞增殖反应 ,迟发型超敏反应的变化。结果 :由刀豆蛋白A ,脂多糖诱导的细胞增殖反应降低 ,脾细胞抗体分泌减少 ,迟发型超敏反应抑制 ,胸腺和脾脏质量降低。结论 :睡眠剥夺可抑制大鼠的免疫功能。
Aim: To explore the relationship between sleep and immune function.Methods:A total of 22 SD rats were divided into 2 groups of 11 each:sleep deprivation group and control group.The immunology methods were used to observe the changes of the proliferative reactivity of spleen cells and delayed hypersensitivity in rats undergoing partial sleep deprivation.Results:The data showed that spleen cell proliferation reaction induced by ConA or LPS obviously decreased and functions of spleen antibody secreting cells were obviously suppressed after sleep deprivation.Four d after sleep deprivation,delayed hypersensitivity was obviously suppressed.The thymuses and spleens of rats deprived sleep were atrophied,and the histology of immune organs had not changed.Conclusion:The study suggests that sleep deprivation can suppress the immune reactions
出处
《河南医科大学学报》
北大核心
2001年第5期559-561,共3页
Journal of Henan Medical University
基金
河南省教委科研基金资助 99310 0 0 5
关键词
睡眠
免疫功能
睡眠剥夺
大鼠
sleep
immune function
sleep deprivation
rat
